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While the benefits of L-Glutathione are starting to be recognized, further studies are required to better understand its bioavailability, and its broader impacts on human health

Taken together, these findings indicate that short-term DMSO treatment at low concentrations does not compromise pluripotency, but instead primes cells by modulating the cell cycle, inducing mild cellular stress, and reshaping transcriptional and epigenetic networks

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Thus, while we were not successful in obtaining more reactive analogs at this point, this approach allows us to explain the observed low reactivity at physiological pH and offers a valuable tool for guiding the future design of nucleotide-based inhibitors with optimized preorientation and reactivity profiles, providing a systematic framework for enhancing these compounds reactivities in a targeted manner