These inflammatory processes or the pro-inflammatory cytokines cause transcriptional, post-transcriptional, and epigenetic changes in the expression of the metabolizing enzymes as well as transport proteins of the liver, and, thereby, influence the plasma level, bioavailability and, thus, efficacy of some drugs [18,20]
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2.2.3 Nuclear factor erythroid 2related factor 2 (Nrf2) activation Nrf2, a ubiquitously expressed transcription factor, functions as a master regulator of cellular responses to oxidative stress (Sies and Jones, 2020)
In Small JE, Noujaim DL, Ginat DT, Kelly HR (eds.)
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