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The uremic toxin homocysteine exacerbates the brain inflammation induced by renal ischemia-reperfusion in mice

In the other direction, the brain may exert an influence on the gut, either via the autonomic and enteric nervous systems (downwards black arrows in Figure 2 ), or via activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis (downwards red arrows in Figure 2 ), which will be examined in detail later

After menopause, estrogen production occurs not from the ovaries but at peripheral adipose tissue sites, where estrone is produced [10, 21, 22]