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The concept of t 1/2eff has been described for antiepileptic drugs, where formulations have been designed to blunt high peak plasma concentrations, reduce peak-to-trough fluctuations, and improve adherence

Plasma GHK levels decline with age (from ~200 ng/mL in young adults to ~80 ng/mL by age 60), making it a heavily studied compound in dermal biology, fibroblast research, and tissue remodeling literature

Research has explored effects on cortisol release, neurotransmitter levels including serotonin and GABA, and autonomic nervous system tone

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The more potent the stimulus of activation of leukocytes is, the greater the release of oxidants and the greater the suppression of T lymphocytic function