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Common targets include glutamate/NMDAR overactivity, undermethylation, copper-zinc imbalance, histamine, pyroluria, oxidative stress, toxic burden, and gut inflammation

Nature 2014, 515 (7528), 554557

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NZB/NZW F1 lupus model A spontaneous model of lupus generated by crossing NZB and NZW mice, producing offspring (F1) that develop a female-biased, late-onset lupus-like disease