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Piperine may also interfere with efflux drug transporters and phase I cytochrome P450 enzymes and increase the bioavailability and slow the elimination of a number of drugs, including phenytoin (Dilantin), propranolol (Inderal), theophylline, and carbamazepine (Tegretol) (121-123)

In rare cases, patients receiving ketoconazole have reported hypersensitivity reactions and even anaphylaxis

Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 Structural insights of GSAAT protein

lets sponsor a 5- to 10-year research protocol to examine it, and let the FDA evaluate that data when its complete

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