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A comprehensive 2025 review in Molecules compiled evidence that the AEDG peptide has been studied for its influence on expression of key antioxidant genes, including SOD2 (superoxide dismutase 2), CAT (catalase), and HMOX1 (heme oxygenase-1) (8)
It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated
Many dermatologists now recommend copper peptides for patients who cannot tolerate retinoids or as part of alternating protocols that reduce retinoid frequency while maintaining anti-aging activity
Melittin, apamin, hyaluronidase, and PLA2 levels are particularly sensitive to change