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One of these classes (class I ferroptosis-inducing compounds, erastin derivatives) inhibits GPX4 through the depletion of glutathione, and the other (class II ferroptosis-inducing compounds, RSL3 derivatives) inhibits GPX4 directly, without glutathione depletion

The former enzyme converts tyrosine to dihydroxyl-phenylalanine (DOPA), which is further converted to DA via AADC catalyzation having pyridoxal phosphate as a cofactor [12]

This positions copper peptide as relatively safe for breaks, cycling, or discontinuation compared to more aggressive treatments requiring continuous use for maintaining results or risking rebound worsening

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