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Interestingly, this sequence has been found to be completely conserved in different mammalian species

In general, the H2R demonstrates predominantly anti-inflammatory effects: In T-cells, H2R activation can suppress certain T-cell responses and may favor TH2 polarization and production of IL-10 [59]

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The significance of GPXs in response to various abiotic stresses, for instance, cold, drought, heat, oxidative, salt and metal stresses has been discussed in this review