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The cycling protocols commonly recommended are partly based on this theoretical concern, though actual tolerance development has not been documented

The coenzymes of this vitamin are highly unstable in light (6)

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General guidelines suggest individuals under 150 pounds may start with 50-75mg daily, those between 150 and 200 pounds typically use 75mg daily as a standard protocol, and individuals over 200 pounds may need 75-100mg daily for optimal effects