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33,34,35,36,37 One study suggests that length of time from diagnosis of cognitive impairment is important for response rate, in that patients who had experienced symptoms for less than 12 months improved on B12, whilst those with symptoms for more than 12 months continued to decline

Potential risks include unpredictable pharmacokinetic interactions, immunogenicity, injection site reactions, gastrointestinal adverse effects, and disruption of copper homeostasis

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