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The researcher will assess the patients eligibility and obtain written informed consent (Additional file 5)

Once the voltage drops to 15.9 volts or less the APS-12 will turn back ON.

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3.2.3 Influence on cardiovascular biomarkers Acute effects on biomarkers across five studies involving healthy populations with a history of smoking, including a randomized crossover study between tobacco smokers and non-smokers, demonstrated that active e-cigarette use in smokers and passive use in healthy individuals did not affect blood count markers