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Bepranemab, a monoclonal antibody against the microtubule-binding region, showed biomarker improvement in a Phase 2 study that ended in 2024, but people enrolled in the trial had no change in cognition

The influence of estrogen on hippocampal cell proliferation is mediated through estrogen receptors (ER) as estradiol-induced cell proliferation in the hippocampus can be inhibited by ER antagonist [142], whereas ER agonist enhances cell proliferation [143]

People get vitamin B12 primarily from animal products, including eggs, meat, dairy products, and fish, so a balanced diet can easily achieve the needed levels of this nutrient

Note: Minimize exposure to moisture and repeated freezethaw cycles