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The senior study author proposed this scenario would cause, hypothyroidism in muscle, with poor activation of the mitochondria and consequently low ATP levels (explaining fatigue and PEM). Further study is needed, but the authors suggested that selenium supplements plus pure T3 could be helpful

Aids in immune responses and controls inflammation

[DOI] [PubMed] [Google Scholar] 48.Lovric-Bencic M., Sikiric P., Hanzevacki J.S., Seiwerth S., Rogic D., Kusec V., Aralica G., Konjevoda P., Batelja L., Blagaic A.B

These findings collectively validate 'metabolic remodeling' as a viable approach to overcome resistance

This is exactly why the dose schedule uses 4-week intervals