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The effect of breadmaking on the retention of two fortificants, folic acid and 5-methyl-THF, in wholemeal rye bread was compared

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Lactate subsequently triggers histone lactylation, especially H4K8/12la, as well as H3K18la, enhancing paired-box gene 6 (PAX6) expression, which in turn inhibits IDH3, creating a feedback loop of IDH3-lactate-PAX6-IDH3 that worsens AD progression