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Endocrinology 155: 17931805, 2014

The substantia nigra isnt traditionally considered a primary serotonergic center (that distinction belongs to raphe nuclei), yet BPC-157s consistent elevation of serotonin there suggests a unique therapeutic approach

for example, 2-deoxy-d-glucose (2-DG), a drug that can compete with glucose in binding to hexokinase II (HKII) to inhibit cellular glycolysis activity and regulate the glycolytic pathway, induces Treg cell differentiation and suppression and alleviates the progression of systemic lupus erythematosus (SLE) in TC mice (209)