B12 Supplements (MAJOR EFFECT) Oral B12 Supplements: Typical dose: 1000 mcg (1 mg) Absorption: ~1-2% passively absorbed (10-20 mcg from 1000 mcg dose) Effect on serum B12: Can increase by 100-300 pg/mL within 24 hours Peak effect: 4-8 hours after oral supplement Intramuscular B12 Injections: Dose: Usually 1000 mcg Effect: Massive increase in serum B12 Can reach 1000-5000 pg/mL within hours Sustained elevation for weeks Recommendation: Stop oral supplements 3-7 days before testing (ideally 7 days) Wait 1-2 weeks after injection before testing 2
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It also serves as a carrier for copper, an essential cofactor for critical antioxidant enzymes like superoxide dismutase (SOD1)
If semaglutide or tirzepatide produce significant weight loss that you maintain, the health benefits (reduced diabetes risk, improved cardiovascular health, better mobility) provide substantial long-term value
Consult your healthcare provider or the pharmacy that provided the medication