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Folic acid may also reduce the risk for Down Syndrome

10.3390/genes12101581 7 AkiyamaH.CarterB

Biomolecules 10 , 1683 (2020)

Smart Image Examples Embodiment 1 [0087] Example 1: Preparation of Intermediate a [0088] Weigh Boc-Ala-OH (9.5 g, 50 mmol), HBTU (19.0 g, 55 mmol) and HOBT (8.1 g, 50 mmol) and dissolve in 250 mL of acetonitrile, add DIPEA (13.5 mL, 100 mmol), and activate at room temperature for 5 mins