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Fatty change and nuclear vacuolisation were not observed

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Inhibition of human osteoclast differentiation by kynurenine through the aryl-hydrocarbon receptor pathway

This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]