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The data show that a substantial number of Phase II awards are attracting Phase III funding, although the figure does not make clear the substantial lags involvedPhase II awards are often ripe for Phase III 4 or more years after the award

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Key molecular features include the F23 Cagri residue anchoring the peptide at the receptor transmembrane (TM) bundle level and the micelle, an E14-R17 intramolecular salt bridge enhancing helical stability, and C-terminal P37 Cagri interaction with the receptor ECD