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In the presence with 10 M hemoglobin, vasorelaxation induced by 100 g/ml BPC 157 was decreased to 12.3 2.3% (Fig
Although these direct antioxidant effects are observable in vitro, their significance in vivo appears limited, stemming from low plasma concentrations of NAC and the prevalence of more abundant endogenous antioxidants such as GSH, ascorbate, and antioxidant enzymes (e.g., SODs, GPs, CAT) [6,38,39]
Furthermore, the CoFe2O4 nanoplatform (CFAP), functionalized with polyethylene glycol (PEG)-coated gold nanoparticles, effectively depletes GSH, disrupts intracellular redox balance, and induces immunogenic cell death, exhibiting promising clinical potential for solid tumor treatment (Zeng et al., 2024)
doi: 10.1111/nmo.13682 103
10.1155/2021/6699560 92 SalmanS.UmarZ.XiaoY
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