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To mitigate placebo effects, crossover designs with washout periods (e.g., 4 weeks) are advantageous

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Individuals with reduced activity of the DHFR enzyme, which is responsible for the first step in folic acid metabolism, may be less able to convert folic acid efficiently

This work was supported by National Natural Science Foundation of China 82074376 and 82374388, the Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine SZ2021ZZ50, Guangdong Provincial Science and Technology Project 2022A1515012051