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The FXR belong to the superfamily of nuclear receptors

These were washed with ice-cold PBS for 5min and fixed in formalin for 15min on ice

In addition to HPA dysregulation, bipolar disorder may be associated with excessive sympathetic nervous system (SNS) activity

It is well tolerated, easy for patients to self-administer, and it keeps mitochondrial support steady through the period when the body is doing the most cellular work

It has versatile pharmacological effects, including antioxidant, anti-ageing [128], gut microbiota regulation [251], anti-obesity [255], antitumour [125], and antidepressant properties [40], which are believed to confer medicinal benefits