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We used metformin in a mouse model of Lafora disease, a devastating form of progressive myoclonus epilepsy, and showed that it reduces some of the hallmarks of the disease, such as the accumulation of polyglucosans and polyubiquitin aggregates in the brain, and reactive astrogliosis, resulting in improvements in the results of neuropsychological tests [77]

They will usually return at some point

Think of it like going to the gym

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And when I kind of spoke to my MD counterparts, I learned early on that this was more treating symptoms in the pharmaceutical approach rather than something that's treating kind of root cause medicine or underlying drivers