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PMID: 171 CampoCGangemiSPioggiaGAllegraA

They have been studied for their effects on bone density, wound healing, sleep quality, and cognition, among other outcomes

Consistent with Leydig cells from elderly men, immunofluorescent staining showed FOXO4 predominantly localized in the nucleus of these H 2 O 2 -induced senescent TM3 Leydig cells, but in the cytoplasm of untreated controls (Figure 3B)

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Histones Likewise, histone acetylation and/or methylation patterns induced by melatonin modulate the coding DNA sequences, modifying the balance of the genes to be transcribed, decreasing the transcription of proto-oncogenes and increasing that of tumor suppressor genes [33]