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Several FXR agonists that have been assessed in clinical trials and their effects are: Obeticholic Acid (OCA): A derivative/synthetic variant of bile acid, it improves insulin sensitivity, liver inflammation, hepatocellular ballooning and reduces fibrosis (218)

Clin Chem Lab Med (CCLM)

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The TCAC utilizes two electron carriers, nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH 2 ) to shuttle electrons to complexes I and II of the ETC, respectively

Central to ferroptosis is the dysregulation of iron metabolism, which is typically controlled by iron-regulatory proteins, such as transferrin and ferritin