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Signs of premature skin aging, including acquired cutis laxa of the extremities and skin wrinkling, although less specific, might also help in the differential with hEDS, especially in adults

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Acknowledgements We sincerely appreciate the superb assistance of Cheltus Cheyuo MD of the Feinstein Institute for Medical Research, New York for help writing the revised manuscript

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The only other prescription smoking cessation drug approved by the FDA, varenicline (Chantix), has been As of November 2021, the temporary recall is still in effect