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In animal models, CagriSema preserved energy expenditure during weight loss by maintaining mitochondrial leak respiration in skeletal muscle

Data were acquired in counting mode at a defocus range of 1.2 m to 1.8 m, yielding a pixel size of 0.85 at the specimen level

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10.1038/nature10427 Nature 88 ZaninottoF.La CameraS.PolverariA.DelledonneM

Also please keep in mind that what a biomarker is not as defined by FDA A biomarker is not an assessment of how an individual feels, functions, or survives