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However, snapshots collected from the last 10 ns MD simulation trajectory of the mh-Tyr-C3G docked complex ( 74.51 20.49 kcal/mol) revealed substantial binding free energy against positive control, i.e., mh-Tyr-ARB inhibitor complex ( 31.09 8.76 kcal/mol)

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In some embodiments, the otic formulation or composition comprises about 0.03% by weight of the silicon dioxide

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