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showed that IGF1 LR3 had about 100-fold lower affinity for IGFBP-3 compared to native IGF-1, while retaining similar receptor binding characteristics

It was demonstrated that cabazitaxel is highly toxic to hepatocellular carcinoma cell lines in a time- and dose-dependent manner by inducing G2/M phase arrest and apoptosis in vitro

IGF-1 and IGFBP-3 were measured at baseline, Year-1 and Year-3

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