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Patients in the semaglutide treatment arm of STEP 1 were more likely to be exposed to the medication at the full dose of 2.4 mg than those in SELECT

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And its not because of any magic its because these are natural substances that our bodies make and are familiar with, so thats what gives them this incredible safety profile. The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs