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Choi S, Lee K, Park SM (2021) Combined associations of changes in noncombustible nicotine or tobacco product and combustible cigarette use habits with subsequent short-term cardiovascular disease risk among South Korean men: a nationwide cohort study

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Nicotine directly binds nAChRs along dopamine neuronal cells, facilitating burst firing and increased dopamine activity directly (96), which, combined with enhanced glutamatergic tone, leads to an overall increased level of dopamine transmission and release in the NAc that supports the reinforcing effects of nicotine (97)

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Spontaneous rupture of large arteries did not occur in our cohort