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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

Screening is part of the standard evaluation process

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However, these models are important because they mimic pathology of NTG, including RGC loss, optic nerve atrophy, and visual impairment with normal IOP 2,3

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