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Modern indoor lifestyles, limited sun exposure, dietary restrictions, and absorption issues have made combined deficiencies common

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A growing body of preclinical research continues to explore its mechanisms and applications, including emerging work on neuroprotective effects and potential roles in spinal cord injury recovery

Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates

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