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Sleep deprivation is a common cause of dark circles, as it can make the skin appear paler and highlight the blood vessels beneath the eyes

Improvements in clinical trials methodologies, the introduction of no fewer than nine biologic agents with distinct mechanisms of action, and the development of better strategies for the use of such agents have all contributed to the new age in RA therapeutics

A review of 11 randomised controlled trials, covering 805 patients, found that collagen hydrolysate taken daily at doses between 2.5g and 10g, over 8 to 24 weeks, led to measurable gains in skin elasticity and hydration

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