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Collagen degradation and barrier disruption The 4,000+ chemicals in cigarette smoke damage collagen and elastin, the structural proteins that maintain lip firmness and elasticity

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However, the authors were unable to pin the negative effect on nicotine alone, implicating an unknown mechanism in the vaping process and suggesting further investigation is needed

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Klonizakis, M., Gumber, A., McIntosh, E., & Brose, L