2015 NNMT consumes SAM as a methyl donor, competing with DNA and histone methyltransferases
In those trials, many participants lost a significant percentage of body weight when combined with lifestyle changes
To help, we asked an expert to weigh in on the matter
Common side effects include: Injection site reactions mild pain, redness, swelling, or bruising at the injection site, typically resolving within a few days Headache usually transient and manageable with standard analgesia Nausea or dizziness particularly in the initial treatment phase Skin reactions including itching, mild rash, or acneiform eruptions Temporary urine discolouration red or orange urine is harmless and expected Diarrhoea or flushing usually mild and self-limiting In patients with severe megaloblastic anaemia, low potassium levels (hypokalaemia) may occur during initial intensive treatment, but this is uncommon in routine maintenance therapy
Regular measurement of hematologic parameters is recommended in all patients on chronic metformin treatment
