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Most Common Adverse Events Key Observations: Gastrointestinal adverse events are dose-dependent and most pronounced during dose escalation Symptoms typically peak within the first 4-8 weeks and diminish with continued treatment as tolerance develops Slow titration (4-week intervals) significantly reduces the incidence and severity of GI events Most adverse events classified as mild to moderate in severity [9] Discontinuation Rates 7.3% Placebo discontinuation rate [9] 15.8% Cagrilintide 2.4 mg (optimal dose) [9] 24.5% Cagrilintide 4.5 mg (high dose) [9] The majority of discontinuations due to adverse events occurred during the titration phase, with GI symptoms (nausea, vomiting) being the primary reasons

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Injectable B12 for Severe Deficiency Cases Seniors with very low Vitamin B12 levels might need injectable B12

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

Cells in the lining of the stomach produce intrinsic factors, and if these cells are damaged or if the stomach is otherwise unable to produce it, vitamin B12 absorption can be impaired