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Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

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In theoretical and model simulation studies, homeostasis of total synaptic drive is typically achieved by normalization: after each iteration of learning and changes of the weights at a subset of synapses, the weights of all synapses are adjusted so that their total sum (or squared sum) remains constant (Von der Malsburg, 1973

Based on these observations, it is most likely that the age-related change in GH secretion is multifactorial in etiology and is primarily caused by changes above the pituitary level