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Cagrilintide is a long-acting analog of amylin (islet amyloid polypeptide), a pancreatic hormone co-secreted with insulin that induces satiety

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Across the trials, effect sizes differ by peptide class, dosage, and treatment duration, with the most consistent improvements observed in metabolic indicators, such as fasting glucose levels and HOMA-IR, and body composition

Potential Cartilage Protection: Some preliminary data suggests peptides derived from growth hormone may also support cartilage health, although more research is necessary to confirm AOD-9604s specific benefits in this area

Loss of proximal tubular transcription factor Krppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation