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Angewandte Chemie International Edition 54, 28212824 (2015)

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Safety: What is and is not known Animal safety data A 2020 preclinical safety evaluation by Xu and colleagues in Regulatory Toxicology and Pharmacology examined BPC-157 across multiple species mice, rats, rabbits, and dogs and reported no serious toxicity, no genotoxicity, and no embryotoxicity at doses evaluated

Potential Side Effects, Safety Profile, and Regulatory Status of BPC 157 In preclinical studies, BPC 157 caused mild local irritation at the site of administration, which was the most commonly reported side effect but did not appear to lead to long-term issues