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The ascorbate-glutathione pathway is functional in different subcellular compartments and all the enzymes of this pathway exist as multiple isoforms

Studies suggest that IGF-1 LR3 might activate key signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) cascades, both of which are central to cellular proliferation and survival

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A subsequent study that followed 43 patients for up to four years found those with mild dementia or moderate-early dementia who took lipoic acid (600 mg/day), in addition to acetylcholinesterase inhibitors, experienced slower cognitive decline compared to the typical cognitive decline of Alzheimers patients as reported in the literature (102)