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FIGURE 2 This oxidative stress environment can activate immune signalling pathways promoting neuroinflammation through mitochondrial dysfunction and impaired mitophagy, as observed in recent studies on ASD brains (Pinto Payares et al., 2024)

Gosselink JV, Hayashi S, Elliott WM, Xing L, Chan B, Yang L, Wright C, Sin D, Par PD, Pierce J, Pierce R, Patterson A, Cooper J, Hogg JC: Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease

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Thus, the virus can cross the BBB, considering that inflammatory cytokines induce its instability (Daniels et al

The work now is not expanding panels endlessly, but clarifying what meaningfully guides intervention, longitudinal care, and real-world benefit