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Acute antioxidant and cytoprotective effects of sulforaphane in brain endothelial cells and astrocytes during inflammation and excitotoxicity

MS3 precursors were fragmented by HCD and analyzed using the Orbitrap (collision energy 55%, AGC 1.5E5, maximum injection time 120 ms, resolution was 50,000)

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Five more peptides are slated for review next February

Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction