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Outcome Focus: The trials were designed primarily to assess weight loss efficacy, with safety as a secondary outcome

The distance from the pyloric sphincter to the ileocecal junction was used to represent the total length of the small intestine, while the distance from the pylorus to the front of the activated charcoal was measured as the migration distance

Weight reduction: In the phase 2 trial, cagrilintide 4.5 mg weekly produced approximately 10.8% body weight loss over 26 weeks versus 3.0% with placebo [4]

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It increases muscle protein synthesis, reduces protein breakdown, supports glucose and amino acid uptake, and suppresses programmed cell death