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All animal studies were approved by the Animal Care and Use Committee of the Yonsei University College of Medicine (No

doi:10.1111/bju.15161

A combination of focal matrix distortion and activated MMPs could cause some disc cells to lose their weak integrin binding: for example, in the present study exposing receptors for 51 integrin (Fig

THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption