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BPC-157 upregulates growth hormone receptors on tendon fibroblasts while TB-500 uses those receptors for enhanced tissue repair

The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

This peptide has been shown to promote the healing of joint tissues, reduce pain, and improve joint function

Identifying the specific gene-expression changes responsible for this persistence is an open research direction