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Neuropeptide Y (NPY) is one of the most potent appetite-stimulating signals in the hypothalamus

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Different isozymes of APX, which are classified on the basis of their sub-cellular localization, show different structural, and kinetic properties, including the presence of specific conserved domains and signal peptides

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PLP is a cofactor for the synthesis of several neurotransmitters including serotonin, the catecholamines dopamine, norepinephrine, and epinephrine [critical enzyme is aromatic L-amino acid decarboxylase (AADC) which is encoded by the DDC gene and is more commonly referred to as DOPA decarboxylase], and -aminobutyric acid, GABA (critical enzyme is glutamic acid decarboxylase, GAD)