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Overall, these results show that a 3-month clinical intervention with L-GSH supplementation in T2DM subjects resulted in significantly decreased levels of the proinflammatory cytokine IL-6, and a decrease in the oxidative stress marker MDA

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Epigenetic modifications, such as DNA methylation of pro-inflammatory cytokine genes (TNF-, IL-6, and IL-1), further influence RA progression, suggesting targets for nanotechnology-based gene regulation and therapeutic intervention (11)