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Knockout of the gamma-aminobutyric acid receptor subunit alpha4 reduces functional delta-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty

The Ukrainian Biochemical Journal

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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition